Database : HANSEN Search on : IMUNIDADE CELULAR [Subject descriptor] References found : 89 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 17773 Author: Arruda, M. S.M; Astolfi, C. S. Title: Algumas consideraçoes a respeito da reaçao de Rubino / ver / Some considerations regarding the reaction of Rubino Source: Hansen. int;10(1/2):5-9, Jan-Dez. 1985. tab. Abstract: Sao comentados alguns aspectos relativos a reaçao de Rubino, visando tanto uma melhor identificaçao dos elementos envolvidos como despertar o interesse dos pesquisadores para esta prova. Os seguintes aspectos sao discutidos: 1) influencia da temperatura sobre os elementos da reaçao; 2) correlaçao entre a reaçao de Rubino e: a) alteraçao humorais observadas na hanseniase, b) imunidade mediata por celulas; 3) variaçoes na reatividade sorologica; 4) valor prognostico e crerio de cura.(AU). Descriptors: HANSENIASE/compl HANSENIASE/diag HANSENIASE/imunol IMUNIDADE CELULAR/imunol IMUNIDADE CELULAR/fisiol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/fisiol Limits: ESTUDO COMPARATIVO HUMANO Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v01aov20/1985/PDF/v10n1-2a02.pdf / Pt Location: BR191.1

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Id: 17691 Author: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Title: The continuing challenges of leprosy ..- Source: s.l; s.n; 2006. 44 p. ilus, tab. Abstract: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descriptors: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limits: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09365/S

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Id: 17553 Author: Bottasso, O. A; Morini, J. C Title: Imunopatologia de la lepra Immunopathology of leprosy- Source: s.l; s.n; 1989. 3 p. . Abstract: Se comentan los estudios en convivientes íntimos de enfermos de Lepra, donde se observó una relación inversa entre grado y tiempo de exposición al Mycobacterium leprae (MI) y la magnitud de la respuesta inmune in vivo hacia el bacilo (reacción de Mitsuda); esta variable por otro lado, se halla influenciada por un importante grado de determinación genética. En un modelo murino experimental, la artritis por adyuvante, también se comprobó que el tratamiento con MI inducia una población de células esplénicas supresoras, con actividad regulatoria sobre la respuesta inmune celular. Se plantean además, las posible alteraciones inmunorregulatorias involucradas con la excesiva respuesta humoral que sirve de sustrato para la generación del episodio de eritema nudoso leproso (ENL) (AU). Descriptors: Imunidade Celular Formação de Anticorpos HANSENIASE/genet HANSENIASE/imunol ARTRITE EXPERIMENTAL/terap TRANSFORMACAO LINFOCITICA ANTIGENO DE MITSUDA/imunol MYCOBACTERIUM LEPRAEMURIUM/imunol Limits: HUMANO ANIMAL RATOS Location: BR191.1; 09332/s

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Id: 17275 Author: Bleharski, Joshua R; Li, Huiying; Meinken, Cristoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Title: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Source: s.l; s.n; 2003. 4 p. . Abstract: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descriptors: Algoritmos Análise por Conglomerados Contagem de Colônia Microbiana Citocinas/GE/ME Perfilação da Expressão Gênica/* Regulação da Expressão Gênica/* Genes de Imunoglobulinas Imunidade Celular Imunidade Natural Hanseníase Virchowiana/*CL/*GE/IM/PP Hanseníase Tuberculóide/*CL/*GE/IM/PP Macrófagos Alveolares/MI Glicoproteínas de Membrana/IM Mycobacterium tuberculosis/GD/IM Análise de Sequência com Séries de Oligonucleotídeos Reação em Cadeia da Polimerase Análise de Componente Principal Receptores da Superfície Celular/IM Receptores Imunológicos/GE/ME Limits: Humano Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Regulação para Cima Location: BR191.1; 09174/s

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Id: 13656 Author: Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Title: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Source: s.l; s.n; Sep. 2003. 4 p. graf. Abstract: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descriptors: HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/fisiopatol HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/genet HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/fisiopatol CITOCINAS/genet CITOCINAS/metab PERFILACAO DA EXPRESSÃO GÊNICA ANALISE POR CONGLOMERADOS CONTAGEM DE COLÔNIA MICROBIANA REGULACAO DA EXPRESSÃO GÊNICA IMUNIDADE CELULAR IMUNIDADE NATURAL MACROFAGOS ALVEOLARES/microbiol GLICOPROTEINAS DE MEMBRANA/imunol MYCOBACTERIUM TUBERCULOSIS/cresc MYCOBACTERIUM TUBERCULOSIS/imunol REACAO EM CADEIA DA POLIMERASE RECEPTORES IMUNOLOGICOS/genet RECEPTORES IMUNOLOGICOS/metab RECEPTORES DA SUPERFICIE CELULAR/imunol - REGULACAO PARA CIMA  Análise de Componente Principal  ALGORITMOS  GENES DE IMUNOGLOBULINAS  ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS Limits: SUPPORT, NON-U.S. GOV'T HUMANO SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09142/s; BR191.1; 09145/s

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Id: 13576 Author: Storrs, Eleanor E; Walsh, G. P; Burchfield, H. P Title: Development of leprosy in another species of armadillo Dasypus hybridus (L): genetic and immunologic implications ..- Source: s.l; s.n; Oct-Nov. 1975. 3 p. ilus. Abstract: The leprosy bacillus (Mycobacterium leprae) was discovered in 1873 and was the first bacterium to be associated with a human disease; yet leprosy is one of the least understood of all bacterial diseases.(AU). Descriptors: XENARTROS/microbiol TEMPERATURA CORPORAL IMUNIDADE CELULAR TATUS/microbiol HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/vet MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/imunol Limits: ANIMAL Electronic Medium: http://www.ilsl.br Location: BR191.1; 01408/s

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Id: 13572 Author: Varkey, Basil; Rose, Harold D; Lohaus, Gerhard; Sohnle, Peter G Title: Blastomycosis: clinical and immunologic aspects ..- Source: s.l; s.n; jun. 1980. 7 p. ilus, tab. Abstract: Dr. Basil Varkey: Blastomycosis was first described by Gilchrist in 1894. For some 50 years thereafter, progress in the understanding of the various aspects of this disease evolved very slowly.(AU). Descriptors: IMUNIDADE CELULAR DERMATOMICOSES/diag PNEUMOPATIAS FUNGICAS/diag PNEUMOPATIAS FUNGICAS/quimioter PNEUMOPATIAS FUNGICAS/imunol BLASTOMICOSE/diag BLASTOMICOSE/quimioter BLASTOMICOSE/imunol BLASTOMYCES ANFOTERICINA B/uso terap Limits: RELATO DE CASO HUMANO MASCULINO ADULTO MEIA-IDADE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00489/s

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Id: 13552 Author: Freiberger, Harley F; Fudenberg, H. Hugh Title: An appetite for armadillo ..- Source: s.l; s.n; jun. 1981. 8 p. ilus. Abstract: In October 1979, a 70-year-old man was referred and admitted to the Medical University of South Carolina Hospital. Three or four years earlier, he had begun to notice the appearance of raised, nontender lumps on his arms and legs.(AU). Descriptors: DOENCAS DO COMPLEXO IMUNE/imunol IMUNIDADE CELULAR HANSENIASE/imunol PLASMAFERESE LINFOCITOS T/imunol Limits: RELATO DE CASO HUMANO MASCULINO IDOSO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01472/s

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Id: 13544 Author: Convit, Jacinto; Ulrich, Marian Title: Recent advances in the immunology of leprosy ..- Source: s.l; s.n; apr. 1976. 14 p. ilus. Abstract: For many decades, interest in leprosy has been largely limited to those areas of the tropical and subtropical world where the disease constitutes an important public health problem.(AU). Descriptors: ANTICORPOS ANTIBACTERIAS COMPLEXO ANTIGENO-ANTICORPO REACOES ANTIGENO-ANTICORPO TECNICAS IMUNOLOGICAS HANSENIASE/quimioter HANSENIASE/imunol HANSENIASE/patol LINFOCITOS/imunol MACROFAGOS/imunol MYCOBACTERIUM LEPRAE/imunol - IMUNIZACAO PASSIVA  SINDROMES DE DEFICIÊNCIA IMUNOLOGICA/imunol  IMUNOTERAPIA  VACINACAO  IMUNIDADE  IMUNIDADE CELULAR  TATUS/imunol  MODELOS ANIMAIS DE DOENCAS Limits: HUMANO ANIMAL Electronic Medium: http://www.ilsl.br Location: BR191.1; 00578/s

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Id: 13520 Author: Meyers, Wayne M; Kvernes, Staffan; Staple, Edna M Title: Failure of levamisole to alter the lepromin reaction ..- Source: s.l; s.n; sep. 1975. 3 p. tab. Abstract: In a study of 37 leprosy patients, the oral administration of levamisole failed to provoke an increase in both the Fernandez and Mitsuda reactions to lepromins of human and armadillo origin. We interpret this as evidence against an effective specific immunostimulatory capability of levamisole in leprosy patients under the conditions of the study. Current knowledge of the mechanism of levamisole action supports the concept that the fundamental immunologic defect in lepromatosus leprosy may reside in the lymphocyte and not the macrophage, or the respective related functions of these two cell forms.(AU). Descriptors: LINFOCITOS/imunol MYCOBACTERIUM LEPRAE/isol LEVAMISOL/admin LEVAMISOL/farmacol HANSENIASE/imunol ANTIGENO DE MITSUDA/imunol IMUNIDADE CELULAR/ef drogas TATUS Limits: HUMANO ANIMAL ADULTO MEIA-IDADE IDOSO CAMUNDONGOS SUPPORT, U.S. GOV'T, NON-P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01921/s

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Id: 13486 Author: Roselle, G. A; Kauffman, C. A Title: Amphotericin B and 5-fluorocytosine: effects on cell-mediated immunity ..- Source: s.l; s.n; apr. 1980. 7 p. tab, graf. Abstract: Although single-dose amphotericin B therapy appears to be immunostimulatory in mice, no data are available regarding the effects of chronic anti-fungal drug therapy on the immune system. We studied the effects on the guinea-pig cellular immune system of 4 weeks of treatment with amphotericin B, 5-fluorocytosine, or the combination of both drugs. The in vitro lymphocyte response to phytohaemagglutinin and the specific antigen, picryl human serum albumin (picHSA), were not affected by anti-fungal drug treatment. At 1.5 weeks of therapy with amphotericin B, skin test reactivity to picHSA was significantly reduced but returned toward normal by the end of 3.5 weeks of drug therapy. Macrophage migration inhibitory factor production by guinea-pig peripheral blood lymphocytes was significantly reduced after 4 weeks of amphotericin B therapy. No immunostimulatory properties could be ascribed to amphotericin B. 5-fluorocytosine had no effect on cellular immunity.(AU). Descriptors: TESTES CUTÂNEOS FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/anal CONTAGEM DE LEUCOCITOS LINFOCITOS T/imunol IMUNIDADE CELULAR/ef drogas TRANSFORMACAO LINFOCITICA/ef drogas FLUCITOSINA/farmacol CITOSINA/analog ANFOTERICINA B/farmacol Limits: ANIMAL FEMININO COBAIAS SUPPORT, U.S. GOV'T, NON-P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01306/s

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Id: 13456 Author: Shepard, Charles C; Walker, Laura L; Van Landingham, Rosalind Title: Heat stability of Mycobacterium leprae immunogenicity ..- Source: s.l; s.n; oct. 1978. 7 p. tab, graf. Abstract: The protection provided to mice by vaccines administered intradermally was measured after footpad challenge with Mycobacterium leprae. The protection offered by M. leprae suspensions was not decreased when the vaccines were killed by 60 degrees C heat or at the higher temperatures tested, which included 215 degrees C (autoclave). Even highly purified suspensions retained their immunogenicity. In contrast, the vaccine protection provided by intradermal M. bovis (strain BCG) was markedly reduced when heated to 60 degrees C. The enlargement of the lymph nodes regional to the intradermal vaccines was measured and found generally to parallel the vaccine protection provided by M. leprae and by BCG.(AU). Descriptors: MYCOBACTERIUM BOVIS HANSENIASE/imunol MYCOBACTERIUM LEPRAE/imunol INJECOES SUBCUTÂNEAS INJECOES INTRADERMICAS VACINA BCG IMUNIDADE CELULAR VACINAS BACTERIANAS/admin VACINAS BACTERIANAS/imunol VACINAS BACTERIANAS/normas - CONGELAMENTO  CALOR Limits: ANIMAL CAMUNDONGOS SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 00293/s

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Id: 13414 Author: Closs, O; Kronvall, G Title: Experimental murine leprosy ..- Source: s.l; s.n; 1975. 6 p. ilus, tab. Abstract: Sera from C3H and C57BL mice infected with Mycobacterium lepraemurium (MLM) and from human leprosy patients were examined for antibodies against MLM by a crossed immunoelectrophoresis (CIE) technique. Altogether antibodies against six or seven MLM antigens were found in the mouse sera. After a small inoculum of MLM, C3H mice produced more antibodies than C57BL mice. After a large inoculum both strains produced about the same amount of antibodies but showed qualitative differences in their response patterns. A serum pool from patients with lepromatous leprosy contained antibodies against six MLM antigens; five of these were identical with the antigens against which antibodies were found in infected mice. C57BL mice that had lost their delayed-type hypersensitivity to MLM during the course of a disseminated infection showed a fairly strong antibody response to three antigens and a weak response to three others. Since almost the same spectrum of antibodies, although in lower titres, could be demonstrated in C57BL mice with intact delayed-type hypersensitivity to the bacilli, these antibodies did not seem to interfere with the expression of cell-mediated immunity.(AU). Descriptors: MODELOS ANIMAIS DE DOENCAS ANTIGENOS DE BACTERIAS ANTICORPOS ANTIBACTERIAS HIPERSENSIBILIDADE TARDIA/imunol IMUNIDADE CELULAR IMUNOELETROFORESE BIDIMENSIONAL HANSENIASE/imunol CAMUNDONGOS ENDOGÂMICOS C3H/imunol CAMUNDONGOS ENDOGÂMICOS C57BL/imunol MYCOBACTERIUM LEPRAEMURIUM/imunol Limits: HUMANO ANIMAL FEMININO CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00024/s

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Id: 13337 Author: Convit, J; Pinardi, M. E; Rodríguez Ochoa, G; Ulrich, M; Avila, J. L; Goihman M Title: Elimination of Mycobacterium leprae subsequent to local in vivo activation of macrophages in lepromatous leprosy by other mycobacteria ..- Source: s.l; s.n; jun. 1974. 5 p. ilus. Abstract: This investigation studied the possibility og activating lepromatous macrophages by a local `in vivo` test...(AU). Descriptors: VACINA BCG HANSENIASE/imunol HANSENIASE/patol LINFOCITOS/imunol ANTIGENOS DE BACTERIAS MACROFAGOS/imunol MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAEMURIUM/imunol DERMATOPATIAS/etiol - GRANULOMA/etnol  IMUNIDADE CELULAR  PELE/patol Limits: HUMANO Electronic Medium: http:/www.ilsl.br Location: BR191.1; 01063/s

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Id: 13321 Author: Saha, Kunal; Mittal, Mmdan M; Ray, S. N Title: Consequences of smallpox vaccination in leprosy patients ..- Source: s.l; s.n; sep. 1973. 8 p. tab. Abstract: This study illustrates the consequences of smallpox revaccination in 45 lepromatous, 28 tuberculoid, and 47 normal individuals. Results obtained with leprosy were associated with a relative anergy against the vaccinia virus, the anergy being minimal in the tuberculoid leprosy but marked in the cases with lepromatous leprosy.(AU). Descriptors: HIPERSENSIBILIDADE TARDIA/imunol IMUNIDADE CELULAR IMUNOGLOBULINA A/anal IMUNOGLOBULINA G/anal IMUNOGLOBULINA M/anal INJECOES INTRADERMICAS HANSENIASE/imunol VACINA ANTIVARIOLICA/admin VACINACAO/ef adv VIRUS DA VACÍNIA/imunol - FORMACAO DE ANTICORPOS  CALOR  HEMAGLUTINACAO  IMUNIZACAO SECUNDARIA  INIBICAO (PSICOLOGIA)  MERCAPTOETANOL  COMPLEMENTO/anal  IMUNODIFUSAO Limits: HUMANO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01256/s

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Id: 13310 Author: Dubey, G. K; Joglekar, V. K; Hardas, U. D; Chaubey, B. S Title: A study of cell mediated immunity in leprosy ..- Source: s.l; s.n; apr. 1981. 7 p. tab, graf. Abstract: This paper presents a review of 123 cases of leprosy of different clinical types as regards to their status of cellular immunity. These 123 cases included 41 fresh cases, 18 cases of reaction and 64 cases of leprosy taking antileprosy treatment. Out of 41 untreated cases only 11 turned up for follow up and their lymphoblastic transformation was repeated 4 to 6 months after initiating the treatment. It was observed that cell mediated immunity as expressed in terms of percentage of blast cells is definitely depressed in leprosy, most in LL and least in TT. There is a definite increase in the percentage of blast cells after taking antileprosy treatment. The rise in percentage of blast cells and hence cellular immunity is relatively more in patients treated with Lamprene as compared to those treated with DDS. Reactions also have impact over immunity in leprosy. Thus, most of the patients with ENL show higher values for blast percentage as compared to those with lepra reaction. It appears that serial lymphocyte cultures if done in all cases of leprosy undergoing treatment will help in assessment of individual progress.(AU). Descriptors: IMUNIDADE CELULAR/ef drogas HANSENOSTATICOS/farmacol HANSENOSTATICOS/uso terap HANSENIASE/quimioter HANSENIASE/imunol CLOFAZIMINA/farmacol CLOFAZIMINA/uso terap DAPSONA/farmacol DAPSONA/uso terap Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00771/s

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Id: 13280 Author: Nath, Indira; Van Rood, J. J; Mehra, N. K; Vaidya, M. C Title: Natural supressor cells in human leprosy: the role of HDLA-D-identical peipheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses ..- Source: s.l; s.n; nov. 1980. 8 p. tab. Abstract: Six families with HLA-D-identical siblings suffering from leprosy were studied. Lymphocytes and macrophages isolated from the peripheral blood were co-cultured with allogeneic, HLA-D-identical cells and stimulated with M. Leprae antigens and concanavalin A. tuberculoid patients had circulating lymphocytes which showed marked functional suppression of lymphoproliferative responses to antigen and mitogen. In contrast, lepromatous patients showed weak lymphocyte suppressor activity. Macrophages derived from responder individuals augmented, while those derived from lepromatous patients inhibited, M. leprae-induced proliferation of lymphocytes.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol CONCANAVALINA A/farmacol ANTIGENOS DE HISTOCOMPATIBILIDADE CLASSE II IMUNIDADE CELULAR HANSENIASE/genet HANSENIASE/imunol TRANSFORMACAO LINFOCITICA MACROFAGOS/imunol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00544/s

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Id: 13218 Author: Mehra, Vijay; Bloom, Barry R Title: Induction of cell-mediated immunity to Mycobacterium leprae in guinea pigs ..- Source: s.l; s.n; mar. 1979. 8 p. ilus, tab. Abstract: Guinea pigs immunized with intact or disrupted armadillo-grown human Mycobacterium leprae administered in aqueous or oil vehicles were tested with various dilutions of M. leprae suspended in saline, water-soluble M. leprae extract, purified protein derivative, and a water-soluble extract of normal armadillo tissue. The results demonstrated the following. (i) Under no conditions was any skin test reactivity found to normal armadillo tissue extract. (ii) Positive sensitization to both M. leprae and its water-soluble extract was achieved by sensitizing guinea pigs with M. leprae suspended in Hanks solution or saline. Autoclaved M. leprae in Hanks solution or saline inoculated intradermally was an effective immunogen. Oil suspensions or emulsions were effective at sensitization, but appeared to be no better and, in general, slightly weaker, than simple inoculation in aqueous suspension. (iii) Living BCG failed to reveal a significant adjuvant effect on sensitization to M. leprae. However, cord factor appeared to potentiate slightly the sensitization to M. leprae in aqueous suspension. (iv) The minimum dose required for sensitization with M. leprae in aqueous suspension was 55 micrograms of purified bacilli. (v) Animals inoculated with M. leprae in saline or with M. leprae together with BCG showed positive skin test reactivity to the first skin test application made fully 1 year after the initial sensitization. The efficacy of autoclaved, irradiated M. leprae in aqueous, oil-free medium suggests a relatively safe approach to human vaccination studies.(AU). Descriptors: HANSENIASE/imunol MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol TESTES CUTÂNEOS REACOES CRUZADAS RELACAO DOSE-RESPOSTA IMUNOLOGICA HIPERSENSIBILIDADE TARDIA/imunol IMUNIDADE CELULAR VACINA BCG Limits: ANIMAL COBAIAS TATUS Electronic Medium: http://www.ilsl.br Location: BR191.1; 02201/s

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Id: 12279 Author: Kim, Jenny; Uyemura, Koichi; Van Dyke, Melissa K; Legaspi, Annaliza J; Rea, Thomas H; Shuai, Ke; Modlin, Robert L Title: A role for IL-12 receptor expression and signal transduction in host defense in leprosy ..- Source: s.l; s.n; 2001. 8 p. graf. Descriptors: ANTIGENOS DE BACTÉRIAS PROTEINAS DE LIGAÇAO DE DNA TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR INTERFERON TIPO II INTERLEUCINA-12 INTERLEUCINA-12 HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE FOSFORILAÇAO RECEPTORES DA INTERLEUCINA RECEPTORES DA INTERLEUCINA TRANSDUÇAO DE SINAL LINFOCITOS T TRANSATIVADORES CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08631/s

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Id: 11697 Author: Spierings, Eric; De Boer, Tjitske; Zulianello, Laurence; Ottenhoff, Tom H. M Title: Novel mechanisms in the immunopathogenesis of leprosy nerve damage: the role of Schwann cells, T cells and Mycobacterium leprae ..- Source: s.l; s.n; 2000. 7 p. ilus, graf. Descriptors: HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE APRESENTAÇAO DO ANTIGENO ANTIGENOS DE BACTÉRIAS ANTIGENOS CD4 LINFOCITOS T CD4-POSITIVOS CITOTOXICIDADE IMUNOLOGICA IMUNIDADE CELULAR INTERFERON TIPO II TRANSFORMAÇAO LINFOCITICA DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO FAGOCITOSE CÉLULAS DE SCHWANN LINFOCITOS T CÉLULAS TH1 Location: BR191.1; 08490/s

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